Fenben for cancer is a controversial topic as it is an anthelmintic drug widely used to treat parasites and worms (pinworms, giardia, roundworms, hookworms, and whipworms) in various animal species. However, it is also being promoted as a cancer treatment method called the Joe Tippens Protocol.
Social media platforms such as Twitter and Facebook are constructively used by cancer patients to exchange information about a variety of medical topics; however, it is easy for nonmedical individuals to disseminate unproven information on these platforms. This raises the risk that patients self-administer inappropriate medicines, which may adversely affect their health. Physicians should always inquire about the source of patients’ information, and should discuss whether dietary supplements or herbs are being taken, in order to ensure that they are appropriate for the patient.
We conducted a semi-structured questionnaire interview with patients with cancer to examine where they obtain false and general cancer information, the quality of their obtained information, and how they perceive it. We interviewed a total of 25 participants, who had been diagnosed with lung or other types of cancer.
In addition to its anthelmintic activity, fenbendazole exhibits antitumor properties in human colorectal cancer cells and patient-derived colon cancer organoids. Among other effects, it alters glucose uptake in cancer cells through down regulation of GLUT transporters and inhibits glycolytic enzymes. Additionally, it interacts with the microtubule-associated protein tubulin and disrupts its polymerization, similar to cytotoxic vinca alkaloids. Furthermore, it induces p53-dependent apoptosis in human colorectal cancer cells and enhances ferroptosis-augmented apoptosis in patient-derived colon cancer organoids. fenben for cancer